Gene

yars1

ID

ZDB-GENE-030425-2

Name

tyrosyl-tRNA synthetase 1

Symbol

yars1 Nomenclature History

Previous Names

TyrRS (1)
yars
cb204 (1)
wu:fk52b08

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have tyrosine-tRNA ligase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Is expressed in several structures, including hematopoietic system; immature eye; mesoderm; musculature system; and nervous system. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb204 (17 images)
IMAGE:6910575 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yars1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate C	Alliance	Charcot-Marie-Tooth disease, dominant intermediate C	608323
		Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2	619418

Associated With yars1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002547	tRNA-binding domain
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002307	Tyrosine-tRNA ligase
Family	IPR051270	Tyrosine-tRNA ligase and regulatory protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Domain Details Per Protein

Protein	Length	Aminoacyl-tRNA synthetase, class Ic	Nucleic acid-binding, OB-fold	Rossmann-like alpha/beta/alpha sandwich fold	tRNA-binding domain	Tyrosine-tRNA ligase	Tyrosine-tRNA ligase and regulatory protein
UniProtKB:A0A0R4I9C1 InterPro	529
UniProtKB:Q6TGS6 InterPro	529

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	yars-201 (1) Ensembl	Ensembl	2,445 nt	Select Tool ZFIN BLAST
mRNA	yars-202 (1) Ensembl	Ensembl	898 nt	Select Tool ZFIN BLAST
mRNA	yars-204 (1) Ensembl	Ensembl	309 nt	Select Tool ZFIN BLAST
mRNA	yars-205 (1) Ensembl	Ensembl	838 nt	Select Tool ZFIN BLAST
mRNA	yars-206 (1) Ensembl	Ensembl	753 nt	Select Tool ZFIN BLAST
mRNA	yars1-208 (1) Ensembl	Ensembl	2,463 nt	Select Tool ZFIN BLAST
ncRNA	yars-002 (1) Ensembl	Ensembl	608 nt	Select Tool ZFIN BLAST
ncRNA	yars-003 (1) Ensembl	Ensembl	758 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations