Gene

krt18a.1

ID

ZDB-GENE-030411-6

Name

keratin 18a, tandem duplicate 1

Symbol

krt18a.1 Nomenclature History

Previous Names

cb83 (1)
DreK18 (1)
krt18
sb:cb83
wu:fa13f02
wu:fb36b04 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including EVL; cardiovascular system; gall bladder; head; and pronephric duct. Human ortholog(s) of this gene implicated in liver cirrhosis and non-alcoholic steatohepatitis. Orthologous to human KRT18 (keratin 18).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 16 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb83 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With krt18a.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cirrhosis, cryptogenic	215600
		{Cirrhosis, noncryptogenic, susceptibility to}	215600

Associated With krt18a.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR039008	Intermediate filament, rod domain
Family	IPR002957	Keratin, type I

Domain Details Per Protein

Protein	Length	Intermediate filament protein, conserved site	Intermediate filament, rod domain	Keratin, type I
UniProtKB:B2GQG8 InterPro	431
UniProtKB:Q7ZTS4 InterPro	431

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	krt18-201 (1) Ensembl	Ensembl	1,749 nt	Select Tool ZFIN BLAST
ncRNA	krt18-002 (1) Ensembl	Ensembl	596 nt	Select Tool ZFIN BLAST
ncRNA	krt18-003 (1) Ensembl	Ensembl	757 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations