Gene

mib1

ID

ZDB-GENE-030404-2

Name

MIB E3 ubiquitin protein ligase 1

Symbol

mib1 Nomenclature History

Previous Names

mib
cg5841 (1)
chunp6889
fe47f05
im:7148100 (1)
KIAA1323 (1)
mind bomb
white tail (3)
wit (3)
wu:fe47f05 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Exhibits identical protein binding activity and ubiquitin-protein transferase activity. Involved in several processes, including animal organ development; nervous system development; and tube morphogenesis. Localizes to endocytic vesicle; perinuclear region of cytoplasm; and protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is expressed in nervous system; neural tube; and pectoral fin. Orthologous to human MIB1 (mindbomb E3 ubiquitin protein ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148100 (1 image)
eu763 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 139 figures from 84 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mib1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Left ventricular noncompaction 7	615092

Associated With mib1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	mib1^{hi904Tg/hi904Tg}	standard conditions	Hortopan et al., 2010

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR010606	Mib-herc2
Domain	IPR040847	Mind bomb, SH3 repeat domain
Domain	IPR042056	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037252	Mib/herc2 domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type	Mib-herc2	Mib/herc2 domain superfamily	Mind bomb, SH3 repeat domain	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:H9GYU5 InterPro	1041
UniProtKB:A0A8M3AMW2 InterPro	1017
UniProtKB:Q804S5 InterPro	1030
UniProtKB:A0A8M3AVC7 InterPro	1006
UniProtKB:A0A8M3AMW8 InterPro	1006
UniProtKB:A0A8M3AYD8 InterPro	1030
UniProtKB:A0A8M3ANM1 InterPro	1040

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mib1-201 (1) Ensembl	Ensembl	4,673 nt	Select Tool ZFIN BLAST
mRNA	mib1-202 (1) Ensembl	Ensembl	3,227 nt	Select Tool ZFIN BLAST
mRNA	mib1-204 (1) Ensembl	Ensembl	3,293 nt	Select Tool ZFIN BLAST
mRNA	mib1-205 (1) Ensembl	Ensembl	698 nt	Select Tool ZFIN BLAST
mRNA	mib1-206 (1) Ensembl	Ensembl	712 nt	Select Tool ZFIN BLAST
ncRNA	mib1-005 (1) Ensembl	Ensembl	1,647 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations