Gene

aldh2.2

ID

ZDB-GENE-030326-5

Name

aldehyde dehydrogenase 2 family member, tandem duplicate 2

Symbol

aldh2.2 Nomenclature History

Previous Names

aldh2
aldh2b
aldh2l
cb154 (1)
wu:fi26c02
zgc:85659

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have aldehyde dehydrogenase (NAD+) activity. Involved in regulation of cellular response to drug. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb154 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aldh2.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Alcohol sensitivity, acute	610251
		{Esophageal cancer, alcohol-related, susceptibility to}
		{Hangover, susceptibility to}	610251
		{Sublingual nitroglycerin, susceptibility to poor response to}

Associated With aldh2.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016160	Aldehyde dehydrogenase, cysteine active site
Conserved_site	IPR029510	Aldehyde dehydrogenase, glutamic acid active site
Domain	IPR015590	Aldehyde dehydrogenase domain
Homologous_superfamily	IPR016161	Aldehyde/histidinol dehydrogenase
Homologous_superfamily	IPR016162	Aldehyde dehydrogenase, N-terminal
Homologous_superfamily	IPR016163	Aldehyde dehydrogenase, C-terminal

Domain Details Per Protein

Protein	Length	Aldehyde dehydrogenase, C-terminal	Aldehyde dehydrogenase, cysteine active site	Aldehyde dehydrogenase domain	Aldehyde dehydrogenase, glutamic acid active site	Aldehyde dehydrogenase, N-terminal	Aldehyde/histidinol dehydrogenase
UniProtKB:Q6TH48 InterPro	516

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	aldh2.2-201 (1) Ensembl	Ensembl		1,904 nt	Select Tool ZFIN BLAST
mRNA	aldh2.2-202 (1) Ensembl	Ensembl		2,125 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations