Gene
prkaa1
- ID
- ZDB-GENE-030325-1
- Name
- protein kinase, AMP-activated, alpha 1 catalytic subunit
- Symbol
- prkaa1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of hh target transcription factor activity. Predicted to be part of nucleotide-activated protein kinase complex. Is expressed in several structures, including axis; digestive system; margin; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb116 (14 images)
- cb130 (29 images)
- IMAGE:7154392 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR028797 | PRKAA1, UBA-like autoinhibitory domain |
| Domain | IPR032270 | AMPK, C-terminal adenylate sensor domain |
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Domain Details Per Protein
| Protein | Length | 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal | AMPK, C-terminal adenylate sensor domain | KA1 domain/Ssp2, C-terminal | PRKAA1/2, autoinhibitory domain | PRKAA1, UBA-like autoinhibitory domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A5WUM0
|
573 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkaa1-201
(1)
|
Ensembl | 3,939 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-278C20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-226M8 | ZFIN Curated Data | |
| Encodes | EST | cb116 | Thisse et al., 2001 | |
| Encodes | EST | cb130 | Thisse et al., 2001 | |
| Encodes | EST | fa94c10 | ||
| Encodes | EST | IMAGE:7154392 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110286 (1) | 1939 nt | ||
| Genomic | GenBank:CR382323 (1) | 143411 nt | ||
| Polypeptide | UniProtKB:A5WUM0 (1) | 573 aa |
No data available
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Thakuri, L.S., Park, C.M., Park, J.W., Rhyu, D.Y. (2023) Gracilaria chorda subcritical-water extracts as ameliorant of insulin resistance induced by high-glucose in zebrafish and dexamethasone in L6 myotubes. Journal of traditional and complementary medicine. 14:829082-90
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- Zhang, Q., Sun, S., Zhang, Y., Wang, X., Li, Q. (2022) Identification of Scd5 as a functional regulator of visceral fat deposition and distribution. iScience. 25:103916
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Ran, C., Xie, M., Li, J., Xie, Y., Ding, Q., Li, Y., Zhou, W., Yang, Y., Zhang, Z., Olsen, R.E., Zhou, Z. (2021) Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish. The Journal of nutrition. 151(10):2986-2996
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