Gene
prkaa1
- ID
- ZDB-GENE-030325-1
- Name
- protein kinase, AMP-activated, alpha 1 catalytic subunit
- Symbol
- prkaa1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in negative regulation of hh target transcription factor activity. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Is expressed in several structures, including axis; digestive system; margin; mesoderm; and nervous system. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb116 (14 images)
- cb130 (29 images)
- IMAGE:7154392 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR028797 | PRKAA1, UBA-like autoinhibitory domain |
| Domain | IPR032270 | AMPK, C-terminal adenylate sensor domain |
| Domain | IPR039137 | 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal |
| Domain | IPR049020 | PRKAA1/2, autoinhibitory domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Length | 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal | AMPK, C-terminal adenylate sensor domain | KA1 domain/Ssp2, C-terminal | PRKAA1/2, autoinhibitory domain | PRKAA1, UBA-like autoinhibitory domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A5WUM0
|
573 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkaa1-201
(1)
|
Ensembl | 3,939 nt |
Interactions and Pathways
No data available
Plasmids
No data available