Gene
chrm2a
- ID
- ZDB-GENE-030314-1
- Name
- cholinergic receptor, muscarinic 2a
- Symbol
- chrm2a Nomenclature History
- Previous Names
-
- chrm2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within cardiac conduction system development and negative regulation of heart rate. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu64 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11876 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Muscarinic acetylcholine receptor family | Muscarinic acetylcholine receptor M2 |
|---|---|---|---|---|---|
|
UniProtKB:B3DKN8
|
495 | ||||
|
UniProtKB:Q801M4
|
495 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrm2a-201
(1)
|
Ensembl | 1,754 nt | ||
| mRNA |
chrm2a-202
(1)
|
Ensembl | 1,605 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117I20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-209O4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-242N8 | ZFIN Curated Data | |
| Encodes | EST | eu64 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:195344 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195354 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178301 (1) | 1488 nt | ||
| Genomic | GenBank:CR356243 (1) | 216472 nt | ||
| Polypeptide | UniProtKB:B3DKN8 (1) | 495 aa |
- Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
- Siregar, P., Audira, G., Feng, L.Y., Lee, J.H., Santoso, F., Yu, W.H., Lai, Y.H., Li, J.H., Lin, Y.T., Chen, J.R., Hsiao, C.D. (2021) Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. toxins. 13(4):
- Jia, S., Wu, X., Wu, Y., Cui, X., Tao, B., Zhu, Z., Hu, W. (2020) Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome. International journal of biological sciences. 16:3039-3049
- Burczyk, M.S., Burkhalter, M.D., Tena, T.C., Grisanti, L.A., Kauk, M., Matysik, S., Donow, C., Kustermann, M., Rothe, M., Cui, Y., Raad, F., Laue, S., Moretti, A., Zimmermann, W.H., Wess, J., Kühl, M., Hoffmann, C., Tilley, D.G., Philipp, M. (2019) Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. JCI insight. 4(20):
- Wang, M., Chen, Y., Zhu, M., Xu, B., Guo, W., Lyu, Y., Zhang, C. (2019) Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and comparative endocrinology. 282:113219
- Zang, L., Shimada, Y., Nakayama, H., Chen, W., Okamoto, A., Koide, H., Oku, N., Dewa, T., Shiota, M., Nishimura, N. (2019) Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Frontiers in genetics. 10:693
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2018) Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. eNeuro. 5(5):
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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