Gene
zic2b
- ID
- ZDB-GENE-030219-92
- Name
- zic family member 2 (odd-paired homolog, Drosophila) b
- Symbol
- zic2b Nomenclature History
- Previous Names
-
- zic2.2 (1)
- zic2l
- hm:zeh0655
- id:ibd5017
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in animal organ development and regulation of retinoic acid receptor signaling pathway. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and neural plate. Orthologous to human ZIC2 (Zic family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Teslaa et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 5 | Alliance | Holoprosencephaly 5 | 609637 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GLI C2H2-type zinc-finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
|
UniProtKB:Q9DE40
|
427 |
Interactions and Pathways
No data available
Plasmids
No data available