Gene

unc119b

ID

ZDB-GENE-030219-130

Name

unc-119 lipid binding chaperone B

Symbol

unc119b Nomenclature History

Previous Names

unc119.1 (1)
zfUnc119b (1)
id:ibd2212
wu:fc47b02
zgc:111863

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable lipid binding activity. Involved in cilium assembly. Acts upstream of or within Kupffer's vesicle development and nervous system development. Predicted to be located in cell projection. Predicted to be active in cilium. Is expressed in several structures, including mesoderm; nervous system; neural plate; pronephric duct; and spinal cord neural tube. Orthologous to human UNC119B (unc-119 lipid binding chaperone B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111863 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wright et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With unc119b Human Ortholog

No data available

Associated With unc119b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR008015	GMP phosphodiesterase, delta subunit
Family	IPR051519	PDE6D/unc-119 myristoyl-binding
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR037036	GMP phosphodiesterase, delta subunit superfamily

Domain Details Per Protein

Protein	Length	GMP phosphodiesterase, delta subunit	GMP phosphodiesterase, delta subunit superfamily	Immunoglobulin E-set	PDE6D/unc-119 myristoyl-binding
UniProtKB:A0A8M9Q9J8 InterPro	261
UniProtKB:Q90Z08 InterPro	243

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	unc119.1-201 (1) Ensembl	Ensembl		5,284 nt	Select Tool ZFIN BLAST
ncRNA	unc119.1-002 (1) Ensembl	Ensembl		540 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Manning et al. (2004, Genesis 40(4):223-230) reported orthology of this gene to UNC119. Subsequent analysis suggests this zebrafish gene is the ortholog of human UNC119B.

Citations