Gene
sult2st1
- ID
- ZDB-GENE-030219-114
- Name
- sulfotransferase family 2, cytosolic sulfotransferase 1
- Symbol
- sult2st1 Nomenclature History
- Previous Names
-
- sult2st (1)
- id:ibd1140
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables sulfotransferase activity and sulfurtransferase activity. Predicted to be involved in sulfation. Predicted to be active in cytoplasm. Is expressed in blood; cardiovascular system; digestive system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14 and prostate cancer. Orthologous to several human genes including SULT2B1 (sulfotransferase family 2B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77668 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|
|
UniProtKB:E7F734
|
287 | ||
|
UniProtKB:Q6P2U4
|
287 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sult2st1-201
(1)
|
Ensembl | 1,284 nt | ||
| mRNA |
sult2st1-202
(1)
|
Ensembl | 864 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-301J1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-176G6 | ZFIN Curated Data | |
| Encodes | EST | ibd1140 | ||
| Encodes | cDNA | MGC:77668 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198914 (1) | 1322 nt | ||
| Genomic | GenBank:CT030207 (1) | 124665 nt | ||
| Polypeptide | UniProtKB:E7F734 (1) | 287 aa |
No data available
- Horzmann, K.A., Lin, L.F., Taslakjian, B., Yuan, C., Freeman, J.L. (2020) Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish. Cell biology and toxicology. 37(3):421-439
- Yamauchi, K., Katsumata, S., Ozaki, M. (2019) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Genes & genetic systems. 94(5):207-217
- Kurogi, K., Yoshihama, M., Horton, A., Schiefer, I.T., Krasowski, M.D., Hagey, L.R., Williams, F.E., Sakakibara, Y., Kenmochi, N., Suiko, M., Liu, M.C. (2017) Identification and characterization of 5α-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the Zebrafish (Danio rerio). The Journal of steroid biochemistry and molecular biology. 174:120-127
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
- Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131
- Mohammed, Y.I., Kurogi, K., Shaban, A.A., Xu, Z., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., Bhuiyan, S., and Liu, M.C. (2012) Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5. Aquatic toxicology (Amsterdam, Netherlands). 112-113C:11-18
- Li, Z.H., Alex, D., Siu, S.O., Chu, I.K., Renn, J., Winkler, C., Lou, S., Tsui, S.K., Zhao, H.Y., Yan, W.R., Mahady, G.B., Li, G.H., Kwan, Y.W., Wang, Y.T., and Lee, S.M. (2011) Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Molecular Biosystems. 7(7):2128-38
- Kurogi, K., Dillon, J., Nasser, A., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.C. (2010) Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs). Drug metabolism letters. 4(2):62-68
- De Wit, M., Keil, D., Remmerie, N., Ven, K.V., Brandhof, E.J., Knapen, D., Witters, E., and Coen, W.D. (2008) Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. Chemosphere. 74(1):96-105
1 - 10 of 14
Show