Gene
col9a2
- ID
- ZDB-GENE-030131-9786
- Name
- procollagen, type IX, alpha 2
- Symbol
- col9a2 Nomenclature History
- Previous Names
-
- cb343 (1)
- sb:cb343
- wu:fa12h02
- wu:fc93e05
- zgc:100808
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including axis; head; hypochord; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in Stickler syndrome; multiple epiphyseal dysplasia 2; and osteochondrodysplasia. Orthologous to human COL9A2 (collagen type IX alpha 2 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb343 (17 images)
- IMAGE:7135988 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020811Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020812Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8661 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9812 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple epiphyseal dysplasia 2 | Alliance | Epiphyseal dysplasia, multiple, 2 | 600204 |
| ?Stickler syndrome, type V | 614284 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Collagen superfamily | Collagen triple helix repeat |
|---|---|---|---|
|
UniProtKB:Q1LXU2
|
691 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col9a2-201
(1)
|
Ensembl | 3,163 nt | ||
| ncRNA |
col9a2-002
(1)
|
Ensembl | 720 nt | ||
| ncRNA |
col9a2-003
(1)
|
Ensembl | 823 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194B5 | ZFIN Curated Data | |
| Encodes | EST | cb343 | Thisse et al., 2001 | |
| Encodes | EST | fa12h02 | ZFIN Curated Data | |
| Encodes | EST | fc93e05 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7135988 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100808 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212579 (1) | 3273 nt | ||
| Genomic | GenBank:BX276085 (2) | 202683 nt | ||
| Polypeptide | UniProtKB:Q1LXU2 (1) | 691 aa |
- Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- He, B.L., Yang, N., Man, C.H., Ng, N.K., Cher, C.Y., Leung, H.C., Kan, L.L., Cheng, B.Y., Lam, S.S., Wang, M.L., Zhang, C.X., Kwok, H., Cheng, G., Sharma, R., Ma, A.C., So, C.E., Kwong, Y.L., Leung, A.Y. (2020) Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. EMBO Molecular Medicine. 12(4):e10895
- Head, B., La Du, J., Tanguay, R.L., Kioussi, C., Traber, M.G. (2020) Vitamin E is necessary for zebrafish nervous system development. Scientific Reports. 10:15028
- Yao, Q., Wang, L., Mittal, R., Yan, D., Richmond, M.T., Denyer, S., Requena, T., Liu, K., Varshney, G.K., Lu, Z., Liu, X. (2019) Transcriptomic Analyses of Inner Ear Sensory Epithelia in Zebrafish. Anatomical record (Hoboken, N.J. : 2007). 303(3):527-543
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108
- Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7
- Wopat, S., Bagwell, J., Sumigray, K.D., Dickson, A.L., Huitema, L.F.A., Poss, K.D., Schulte-Merker, S., Bagnat, M. (2018) Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Reports. 22:2026-2038
- Garcia, J., Bagwell, J., Njaine, B., Norman, J., Levic, D.S., Wopat, S., Miller, S.E., Liu, X., Locasale, J.W., Stainier, D.Y.R., Bagnat, M. (2017) Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Current biology : CB. 27(13):1982-1989.e3
- Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196
1 - 10 of 26
Show