Gene
paics
- ID
- ZDB-GENE-030131-9762
- Name
- phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
- Symbol
- paics Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in chordate embryonic development; pigmentation; and retina development in camera-type eye. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb293 (9 images)
- IMAGE:7145230 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Phosphoribosylaminoimidazole carboxylase deficiency | 619859 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Class II PurE | PurE domain | SAICAR synthetase | SAICAR synthetase/ADE2, N-terminal | SAICAR synthetase, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZUN6
|
425 |
Interactions and Pathways
No data available
Plasmids
No data available