Gene
gsna
- ID
- ZDB-GENE-030131-9653
- Name
- gelsolin a
- Symbol
- gsna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping; actin nucleation; and cell projection organization. Predicted to be located in cell projection and nucleus. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb107 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Finnish type amyloidosis | Alliance | Amyloidosis, Finnish type | 105120 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Villin/Gelsolin |
|---|---|---|---|---|
|
UniProtKB:F1QUM3
|
729 | |||
|
UniProtKB:A0A8M9P366
|
738 |
Interactions and Pathways
No data available
Plasmids
No data available