Gene

relb

ID
ZDB-GENE-030131-9531
Name
v-rel avian reticuloendotheliosis viral oncogene homolog B
Symbol
relb Nomenclature History
Previous Names
  • fj85b02
  • wu:fj85b02
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including innate immune response; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to localize to I-kappaB/NF-kappaB complex; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer and primary immunodeficiency disease. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Diotel et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With relb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 53 Alliance ?Immunodeficiency 53 617585
Associated With relb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030492 Rel homology domain, conserved site
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain, DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Family IPR000451 NF-kappa-B/Dorsal
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain NF-kappa-B/Dorsal p53-like transcription factor, DNA-binding domain superfamily Rel homology dimerisation domain Rel homology domain, conserved site Rel homology domain, DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily
UniProtKB:A0A8M9P750 590
UniProtKB:A0A8M9PC94 573
UniProtKB:A0A8M1Q745 590
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA relb-201 (1) Ensembl 1,080 nt
mRNA relb-202 (1) Ensembl 4,414 nt
mRNA relb-204 (1) Ensembl 1,173 nt
ncRNA relb-002 (1) Ensembl 390 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations