Gene
atp2a2b
- ID
- ZDB-GENE-030131-867
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b
- Symbol
- atp2a2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have calcium transmembrane transporter activity, phosphorylative mechanism and proton-exporting ATPase activity, phosphorylative mechanism. Predicted to be involved in calcium ion transmembrane transport and cellular calcium ion homeostasis. Predicted to localize to sarcoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Is expressed in axis; myotome; pectoral fin; and pectoral fin musculature. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu338 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shim et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrokeratosis verruciformis | Alliance | Acrokeratosis verruciformis | 101900 |
| keratosis follicularis | Alliance | Darier disease | 124200 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IQS8
|
1041 | |||||||||||
|
UniProtKB:Q6ZM60
|
1035 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp2a2b-201
(1)
|
Ensembl | 4,312 nt | ||
| mRNA |
atp2a2b-202
(1)
|
Ensembl | 5,913 nt | ||
| mRNA |
atp2a2b-203
(1)
|
Ensembl | 5,808 nt |
Interactions and Pathways
No data available
Plasmids
No data available