Gene
lig3
- ID
- ZDB-GENE-030131-8453
- Name
- ligase III, DNA, ATP-dependent
- Symbol
- lig3 Nomenclature History
- Previous Names
-
- im:7139055
- im:7145225
- wu:fb12c02
- wu:fd10b03
- wu:fm79b09
- zgc:112973
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining. Predicted to localize to DNA ligase III-XRCC1 complex and mitochondrion. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 20 | Alliance | Mitochondrial DNA depletion syndrome 20 (MNGIE type) | 619780 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016059 | DNA ligase, ATP-dependent, conserved site |
| Domain | IPR001357 | BRCT domain |
| Domain | IPR001510 | Zinc finger, PARP-type |
| Domain | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
| Domain | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
| Domain | IPR012310 | DNA ligase, ATP-dependent, central |
| Domain | IPR031916 | DNA ligase 3, BRCT domain |
| Family | IPR000977 | DNA ligase, ATP-dependent |
| Family | IPR050191 | ATP-dependent DNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
| Homologous_superfamily | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
| Homologous_superfamily | IPR036957 | Zinc finger, PARP-type superfamily |
Domain Details Per Protein
| Protein | Length | ATP-dependent DNA ligase | BRCT domain | BRCT domain superfamily | DNA ligase 3, BRCT domain | DNA ligase, ATP-dependent | DNA ligase, ATP-dependent, central | DNA ligase, ATP-dependent, conserved site | DNA ligase, ATP-dependent, C-terminal | DNA ligase, ATP-dependent, N-terminal | DNA ligase, ATP-dependent, N-terminal domain superfamily | Nucleic acid-binding, OB-fold | Zinc finger, PARP-type | Zinc finger, PARP-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJL4
|
1011 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available