Gene
prg4a
- ID
- ZDB-GENE-030131-8295
- Name
- proteoglycan 4a
- Symbol
- prg4a Nomenclature History
- Previous Names
-
- fb08a02
- wu:fb08a02
- wu:fk21a06
- zgc:56698
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable polysaccharide binding activity and scavenger receptor activity. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Nolte et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| camptodactyly-arthropathy-coxa vara-pericarditis syndrome | Alliance | Camptodactyly-arthropathy-coxa vara-pericarditis syndrome | 208250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001212 | Somatomedin B domain |
| Domain | IPR020436 | Somatomedin B domain, chordata |
| Family | IPR051298 | Heme transport and cell adhesion protein |
| Homologous_superfamily | IPR036024 | Somatomedin B-like domain superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Heme transport and cell adhesion protein | Hemopexin-like domain superfamily | Hemopexin-like repeats | Somatomedin B domain | Somatomedin B domain, chordata | Somatomedin B-like domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PHS8
|
486 |
Interactions and Pathways
No data available
Plasmids
No data available