Gene
sox4a
- ID
- ZDB-GENE-030131-8290
- Name
- SRY-box transcription factor 4a
- Symbol
- sox4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to localize to nuclear transcription factor complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Orthologous to human SOX4 (SRY-box transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 22 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65850 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Coffin-Siris syndrome 10 | Alliance | Coffin-Siris syndrome 10 | 618506 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | High mobility group box domain | High mobility group box domain superfamily | Transcription factor SOX-12/11/4 |
---|---|---|---|---|
UniProtKB:Q6P0Z4
|
363 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-150K17 | ZFIN Curated Data | |
Encodes | EST | fb82f08 | ||
Encodes | EST | fq41g10 | ||
Encodes | cDNA | MGC:65850 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77392 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213122 (1) | 3350 nt | ||
Genomic | GenBank:BX957317 (2) | 222684 nt | ||
Polypeptide | UniProtKB:Q6P0Z4 (1) | 363 aa |
- Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Zafar, I., Iftikhar, R., Ahmad, S.U., Rather, M.A. (2021) Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Biotechnology reports (Amsterdam, Netherlands). 30:e00607
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Chaudhary, M., Kurup, A.J., Ramachandran, R. (2019) Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration. The Journal of cell biology. 218(2):489-507
- You, M.S., Wang, W.P., Wang, J.Y., Jiang, Y.J., Chi, Y.H. (2019) Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish. Stem cells and development. 28(16):1116-1127
- Zimmerman, M.W., Liu, Y., He, S., Durbin, A.D., Abraham, B.J., Easton, J., Shao, Y., Xu, B., Zhu, S., Zhang, X., Li, Z., Weichert-Leahey, N., Young, R.A., Zhang, J., Look, A.T. (2018) MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer discovery. 8:320-335
- Lu, J.W., Hsieh, M.S., Hou, H.A., Chen, C.Y., Tien, H.F., Lin, L.I. (2017) Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood cancer journal. 7:e593
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