Gene
sox4a
- ID
- ZDB-GENE-030131-8290
- Name
- SRY-box transcription factor 4a
- Symbol
- sox4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to localize to nuclear transcription factor complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Orthologous to human SOX4 (SRY-box transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65850 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Coffin-Siris syndrome 10 | Alliance | Coffin-Siris syndrome 10 | 618506 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | Transcription factor SOX-12/11/4 |
|---|---|---|---|---|
|
UniProtKB:Q6P0Z4
|
363 |
Interactions and Pathways
No data available
Plasmids
No data available