Gene

sox4a

ID
ZDB-GENE-030131-8290
Name
SRY-box transcription factor 4a
Symbol
sox4a Nomenclature History
Previous Names
  • sox4
  • wu:fb82f08 (1)
  • wu:fq41g10 (1)
  • zgc:65850
  • zgc:77392 (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to localize to nuclear transcription factor complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Orthologous to human SOX4 (SRY-box transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Human Disease
Associated With sox4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 10 Alliance Coffin-Siris syndrome 10 618506
1 - 1 of 1
Associated With sox4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Family IPR017386 Transcription factor SOX-12/11/4
Homologous_superfamily IPR036910 High mobility group box domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Transcription factor SOX-12/11/4
UniProtKB:Q6P0Z4 363
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sox4a-201 (1) Ensembl 3,261 nt
mRNA sox4a-203 (1) Ensembl 597 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-150K17ZFIN Curated Data
EncodesESTfb82f08
EncodesESTfq41g10
EncodescDNAMGC:65850ZFIN Curated Data
EncodescDNAMGC:77392ZFIN Curated Data
1 - 5 of 5
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSOX46
Phylogenetic tree (2)
Conserved genome location (synteny) (3)
Amino acid sequence comparison (4)
MouseSox413
Phylogenetic tree (1)
Amino acid sequence comparison (2)
Citations
1 - 10 of 29
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