Gene

kidins220b

ID

ZDB-GENE-030131-7824

Name

kinase D-interacting substrate 220b

Symbol

kidins220b Nomenclature History

Previous Names

fj35h03
kidins220 (1)
wu:fj35h03
zgc:63531

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Exhibits PDZ domain binding activity. Predicted to be involved in nervous system development. Predicted to localize to late endosome. Is expressed in hindbrain; motor neurons; and retina. Orthologous to human KIDINS220 (kinase D interacting substrate 220).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63531 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kidins220b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Spastic paraplegia, intellectual disability, nystagmus, and obesity	617296
		Ventriculomegaly and arthrogryposis	619501

Associated With kidins220b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011646	KAP family P-loop domain
Family	IPR052771	Neurotrophin-activated signaling adaptor
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	KAP family P-loop domain	Neurotrophin-activated signaling adaptor
UniProtKB:A0A8M2B7I2 InterPro	1690
UniProtKB:Z4YJ74 InterPro	1680
UniProtKB:Q7T163 InterPro	1680
UniProtKB:A0A8M2B7R5 InterPro	1721
UniProtKB:A0A8M2B7H5 InterPro	1732
UniProtKB:A0A8M2B7H7 InterPro	1731