Gene
syt4
- ID
- ZDB-GENE-030131-7297
- Name
- synaptotagmin IV
- Symbol
- syt4 Nomenclature History
- Previous Names
-
- wu:fj05d11
- zgc:73240
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including calcium ion-regulated exocytosis of neurotransmitter; cellular response to calcium ion; and regulation of secretion by cell. Predicted to act upstream of or within exocytosis. Predicted to be located in membrane. Predicted to be active in axon and synapse. Is expressed in nervous system and neural tube. Orthologous to human SYT4 (synaptotagmin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73240 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Synaptotagmin |
|---|---|---|---|---|
|
UniProtKB:Q6PBU6
|
439 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183C6 | ZFIN Curated Data | |
| Encodes | EST | fj05d11 | ||
| Encodes | cDNA | MGC:73240 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199948 (1) | 2317 nt | ||
| Genomic | GenBank:CR388231 (1) | 179363 nt | ||
| Polypeptide | UniProtKB:Q6PBU6 (1) | 439 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SYT4 | 18 | Amino acid sequence comparison (1) |
- Shiao, M.S., Liu, S.T., Siriwatcharapibool, G., Thongpradit, S., Khunpanich, P., Tong, S.K., Huang, C.H., Jinawath, N., Chou, M.Y. (2024) Conserved expression of the zebrafish syt4 gene in GABAergic neurons in the cerebellum of adult fishes revealed by mammalian SYT4 immunoreactive-like signals. Heliyon. 10:e30575e30575
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Henry, D., Joselevitch, C., Matthews, G.G., Wollmuth, L.P. (2021) Expression and distribution of synaptotagmin family members in the zebrafish retina. The Journal of comparative neurology. 530(4):705-728
- Monestime, C.M., Taibi, A., Gates, K.P., Jiang, K., Sirotkin, H.I. (2019) CoRest1 regulates neurogenesis in a stage-dependent manner. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):918-930
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Moravec, C.E., Samuel, J., Weng, W., Wood, I.C., Sirotkin, H.I. (2016) Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:9407-19
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Love, C.E., Prince, V.E. (2015) Rest represses maturation within migrating facial branchiomotor neurons. Developmental Biology. 401(2):220-35
- Craxton, M. (2010) A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology. BMC Genomics. 11:37
- Craxton, M. (2007) Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. BMC Genomics. 8:259
1 - 10 of 13
Show