Gene
fbp1a
- ID
- ZDB-GENE-030131-7171
- Name
- fructose-1,6-bisphosphatase 1a
- Symbol
- fbp1a Nomenclature History
- Previous Names
-
- fbp1l (1)
- fk92h02
- wu:fk92h02
- zgc:64096
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in several processes, including fructose 1,6-bisphosphate metabolic process; hexose metabolic process; and sucrose biosynthetic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; lens; liver; and solid lens vesicle. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64096 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16323 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fructose-1,6-bisphosphatase deficiency | Alliance | Fructose-1,6-bisphosphatase deficiency | 229700 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020548 | Fructose-1,6-bisphosphatase, active site |
| Domain | IPR033391 | Fructose-1-6-bisphosphatase class I, N-terminal |
| Domain | IPR044015 | Fructose-1-6-bisphosphatase class 1, C-terminal |
| Family | IPR000146 | Fructose-1,6-bisphosphatase class 1 |
| Family | IPR028343 | Fructose-1,6-bisphosphatase |
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Domain Details Per Protein
| Protein | Length | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase, active site | Fructose-1,6-bisphosphatase class 1 | Fructose-1-6-bisphosphatase class 1, C-terminal | Fructose-1-6-bisphosphatase class I, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6PFT1
|
337 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-146L2 | ZFIN Curated Data | |
| Encodes | EST | fk92h02 | ||
| Encodes | cDNA | MGC:64096 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199942 (1) | 1592 nt | ||
| Genomic | GenBank:CR388096 (2) | 139460 nt | ||
| Polypeptide | UniProtKB:Q6PFT1 (1) | 337 aa |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Zhao, T., Ye, Z., Liu, Y., Lin, H., Li, S., Zhang, Y. (2022) Mutation of spexin2 promotes feeding, somatic growth, adiposity and insulin resistance in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 322(5):R454-R465
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:
- Keller, R.M., Beaver, L.M., Reardon, P.N., Prater, M.C., Truong, L., Robinson, M.M., Tanguay, R.L., Stevens, J.F., Hord, N.G. (2021) Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 131(1):142-157
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727
- Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993
- Rajeswari, J.J., Blanco, A.M., Unniappan, S. (2020) Phoenixin-20 (PNX-20) Suppresses Food Intake, Modulates Glucoregulatory Enzymes, and Enhances Glycolysis in Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R917-R928
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