Gene
ptprub
- ID
- ZDB-GENE-030131-7036
- Name
- protein tyrosine phosphatase receptor type Ub
- Symbol
- ptprub Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Acts upstream of or within somite specification. Predicted to be located in membrane. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | MAM domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Receptor-type Tyrosine-protein Phosphatases | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QDT0
|
1440 | |||||||||||||
|
UniProtKB:A0A8M3AI77
|
1433 | |||||||||||||
|
UniProtKB:A0A286YB08
|
1450 | |||||||||||||
|
UniProtKB:A0A8M3ATI7
|
1449 | |||||||||||||
|
UniProtKB:A0A8M3AI73
|
1447 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptprub-201
(1)
|
Ensembl | 434 nt | ||
| mRNA |
ptprub-202
(1)
|
Ensembl | 4,547 nt | ||
| mRNA |
ptprub-203
(1)
|
Ensembl | 4,640 nt | ||
| mRNA |
ptprub-204
(1)
|
Ensembl | 4,658 nt | ||
| mRNA |
ptprub-205
(1)
|
Ensembl | 4,628 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-120E13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-200N15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-164F21 | ZFIN Curated Data | |
| Encodes | EST | fj42a04 | ||
| Encodes | EST | fk66g06 | ||
| Encodes | cDNA | MGC:194790 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194809 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002299 (1) | 4559 nt | ||
| Genomic | GenBank:CR385021 (2) | 148046 nt | ||
| Polypeptide | UniProtKB:A0A286YB08 (1) | 1450 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PTPRU | 1 | Amino acid sequence comparison (2) |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Vrljicak, P., Tao, S., Varshney, G.K., Quach, H.N., Joshi, A., LaFave, M.C., Burgess, S.M., Sampath, K. (2016) Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility. G3 (Bethesda). 6(4):805-17
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.C., Lutfalla, G., Möröy, T., Abou Elela, S., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015) Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One. 10:e0125998
- Quach, H.N., Tao, S., Vrljicak, P., Joshi, A., Ruan, H., Sukumaran, R., Varshney, G.K., LaFave, M.C., Screen Team, T.D., Burgess, S.M., Winkler, C., Emelyanov, A., Parinov, S., Sampath, K. (2015) A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda). 5(6):1283-99
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
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