Gene
orc1
- ID
- ZDB-GENE-030131-6960
- Name
- origin recognition complex, subunit 1
- Symbol
- orc1 Nomenclature History
- Previous Names
-
- orc1l
- wu:fa11h08
- zgc:55976 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have DNA replication origin binding activity. Involved in chordate embryonic development; regulation of growth; and response to yeast. Predicted to localize to nuclear chromosome, telomeric region and nuclear origin of replication recognition complex. Is expressed in proliferative region and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55976 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Meier-Gorlin syndrome 1 | Alliance | Meier-Gorlin syndrome 1 | 224690 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR003959 | ATPase, AAA-type, core |
Domain | IPR015163 | Cdc6, C-terminal |
Domain | IPR041083 | AAA lid domain |
Family | IPR050311 | Origin Recognition Complex 1/Cell Division Control Protein 6 |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR043151 | Bromo adjacent homology (BAH) domain superfamily |
Domain Details Per Protein
Protein | Length | AAA+ ATPase domain | AAA lid domain | ATPase, AAA-type, core | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | Cdc6, C-terminal | Origin Recognition Complex 1/Cell Division Control Protein 6 | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7ZYW6
|
910 | ||||||||
UniProtKB:F1QLF9
|
912 | ||||||||
UniProtKB:A0A8M9PM45
|
873 |
Interactions and Pathways
No data available
Plasmids
No data available