Gene
nfkb2
- ID
- ZDB-GENE-030131-6701
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
- Symbol
- nfkb2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and cholesterol homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in brain; liver; male organism; and retina. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012310Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22283 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22284 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35472 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35473 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 10 | Alliance | Immunodeficiency, common variable, 10 | 615577 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Death domain | Death-like domain superfamily | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | NFkappaB IPT domain | Nuclear factor NF-kappa-B, p100 subunit, RHD domain, N-terminal | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q0II00
|
902 | |||||||||||||||
|
UniProtKB:A0A8M2B350
|
896 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134M17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-150I13 | ZFIN Curated Data | |
| Encodes | EST | fa03b02 | ||
| Encodes | cDNA | MGC:136693 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001840 (1) | 3472 nt | ||
| Genomic | GenBank:BX890597 (1) | 244779 nt | ||
| Polypeptide | UniProtKB:Q0II00 (1) | 902 aa |
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Baniel, A., Ziv, L., Ben-Moshe, Z., Sarig, O., Mohamad, J., Peled, A., Rechavi, G., Gothilf, Y., Sprecher, E. (2022) Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Biomedicines. 10(12):
- Darroch, H., Astin, J.W., Hall, C.J. (2022) Towards a new model of trained immunity: Exposure to bacteria and β-glucan protects larval zebrafish against subsequent infections. Developmental and comparative immunology. 132:104400
- Deng, Z., Hou, K., Valencak, T.G., Luo, X.M., Liu, J., Wang, H. (2022) AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish. Microbiology spectrum. 10(4):e0061022
- Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish. Frontiers in nutrition. 9:870343
- Farr, D., Nag, D., Chazin, W.J., Harrison, S., Thummel, R., Luo, X., Raychaudhuri, S., Withey, J.H. (2022) Neutrophil-associated responses to Vibrio cholerae infection in a natural host model. Infection and Immunity. 90(3):e0046621
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