Gene
abcb5
- ID
- ZDB-GENE-030131-6414
- Name
- ATP-binding cassette, sub-family B (MDR/TAP), member 5
- Symbol
- abcb5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within detoxification of mercury ion. Predicted to be active in membrane. Is expressed in EVL; epidermis; liver; periderm; and pharyngeal arch. Orthologous to human ABCB5 (ATP binding cassette subfamily B member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158730 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
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Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R7A8
|
1338 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-226D12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-180P9 | ZFIN Curated Data | |
| Encodes | EST | fc18f02 | ||
| Encodes | EST | fi81f06 | ||
| Encodes | EST | IMAGE:7158730 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001922682 (1) | 4952 nt | ||
| Genomic | GenBank:BX005032 (2) | 155001 nt | ||
| Polypeptide | UniProtKB:F1R7A8 (1) | 1338 aa |
- Robey, R.W., Robinson, A.N., Ali-Rahmani, F., Huff, L.M., Lusvarghi, S., Vahedi, S., Hotz, J.M., Warner, A.C., Butcher, D., Matta, J., Edmondson, E.F., Lee, T.D., Roth, J.S., Lee, O.W., Shen, M., Tanner, K., Hall, M.D., Ambudkar, S.V., Gottesman, M.M. (2021) Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter. Scientific Reports. 11:24150
- Bieczynski, F., Burkhardt-Medicke, K., Marcelo Luquet, C., Scholz, S., Luckenbach, T. (2020) Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity. FEBS letters. 595(6):828-843
- Kim, C., Choe, H., Park, J., Kim, G., Kim, K., Jeon, H.J., Moon, J.K., Kim, M.J., Lee, S.E. (2020) Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: Visualization of abnormal development using two transgenic lines. Environmental pollution (Barking, Essex : 1987). 270:116087
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Hamid, N., Junaid, M., Pei, D.S. (2019) Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of hazardous materials. 382:121106
- Junaid, M., Wang, Y., Hamid, N., Deng, S., Li, W.G., Pei, D.S. (2019) Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. Journal of hazardous materials. 380:120828
- Qiao, R., Lu, K., Deng, Y., Ren, H., Zhang, Y. (2019) Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish. The Science of the total environment. 682:128-137
- Zhu, X.Y., Guo, D.W., Lao, Q.C., Xu, Y.Q., Meng, Z.K., Xia, B., Yang, H., Li, C.Q., Li, P. (2019) Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Scientific Reports. 9:4541
- Liu, Y., Junaid, M., Wang, Y., Tang, Y.M., Bian, W.P., Xiong, W.X., Huang, H.Y., Chen, C.D., Pei, D.S. (2018) New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquatic toxicology (Amsterdam, Netherlands). 201:151-161
- Zhang, Y., Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J., Liu, K. (2018) The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae. Human & Experimental Toxicology. 38(1):36-44
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