Gene
adsl
- ID
- ZDB-GENE-030131-6363
- Name
- adenylosuccinate lyase
- Symbol
- adsl Nomenclature History
- Previous Names
-
- fi60b04
- wu:fi60b04
- zgc:56061 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Dutto et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adenylosuccinase lyase deficiency | Alliance | Adenylosuccinase deficiency | 103050 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020557 | Fumarate lyase, conserved site |
| Domain | IPR019468 | Adenylosuccinate lyase C-terminal |
| Domain | IPR022761 | Fumarate lyase, N-terminal |
| Family | IPR000362 | Fumarate lyase family |
| Family | IPR004769 | Adenylosuccinate lyase |
| Homologous_superfamily | IPR008948 | L-Aspartase-like |
Domain Details Per Protein
| Protein | Length | Adenylosuccinate lyase | Adenylosuccinate lyase C-terminal | Fumarate lyase, conserved site | Fumarate lyase family | Fumarate lyase, N-terminal | L-Aspartase-like |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R293
|
482 |
Interactions and Pathways
No data available
Plasmids
No data available