Gene

brf1a

ID

ZDB-GENE-030131-6334

Name

BRF1 general transcription factor IIIB subunit a

Symbol

brf1a Nomenclature History

Previous Names

brf1
wu:fi47f03
zgc:55543 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have RNA polymerase III type 3 promoter sequence-specific DNA binding activity and transcription factor binding activity. Involved in neutrophil differentiation. Predicted to localize to transcription factor TFIIIB complex. Is expressed in several structures, including head; midbrain; notochord; pectoral fin musculature; and polster. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55543 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Bielczyk-Maczyńska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brf1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellofaciodental syndrome	Alliance	Cerebellofaciodental syndrome	616202

Associated With brf1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011665	Brf1, TBP-binding domain
Domain	IPR013137	Zinc finger, TFIIB-type
Domain	IPR013150	Transcription factor TFIIB, cyclin-like domain
Domain	IPR013763	Cyclin-like domain
Family	IPR000812	Transcription factor TFIIB
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Length	Brf1, TBP-binding domain	Cyclin-like domain	Cyclin-like superfamily	Transcription factor TFIIB	Transcription factor TFIIB, cyclin-like domain	Zinc finger, TFIIB-type
UniProtKB:F1R9S3 InterPro	661
UniProtKB:Q802Z8 InterPro	661

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brf1a-201 (1) Ensembl	Ensembl	5,076 nt	Select Tool ZFIN BLAST
mRNA	brf1a-202 (1) Ensembl	Ensembl	465 nt	Select Tool
mRNA	brf1a-203 (1) Ensembl	Ensembl	2,007 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations