Gene

yars2

ID
ZDB-GENE-030131-6268
Name
tyrosyl-tRNA synthetase 2, mitochondrial
Symbol
yars2 Nomenclature History
Previous Names
  • fi41d10
  • wu:fi41d10
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have tyrosine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With yars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myopathy, lactic acidosis, and sideroblastic anemia 2 Alliance Myopathy, lactic acidosis, and sideroblastic anemia 2 613561
Associated With yars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Family IPR002305 Aminoacyl-tRNA synthetase, class Ic
Family IPR002307 Tyrosine-tRNA ligase
Family IPR024088 Tyrosine-tRNA ligase, bacterial-type
Family IPR024107 Tyrosine-tRNA ligase, bacterial-type, type 1
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR036986 RNA-binding S4 domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ic Aminoacyl-tRNA synthetase, class I, conserved site RNA-binding S4 domain superfamily Rossmann-like alpha/beta/alpha sandwich fold Tyrosine-tRNA ligase Tyrosine-tRNA ligase, bacterial-type Tyrosine-tRNA ligase, bacterial-type, type 1
UniProtKB:A0A8M9PUY4 309
UniProtKB:F1Q4R5 474
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
antisense ottdart00000056263 (1) Ensembl 712 nt
mRNA yars2-201 (1) Ensembl 1,794 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations