Gene

brf1b

ID

ZDB-GENE-030131-6248

Name

BRF1 general transcription factor IIIB subunit b

Symbol

brf1b Nomenclature History

Previous Names

fi40c10
wu:fi40c10
zgc:63497

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within cerebellum development and thrombocyte differentiation. Predicted to be located in membrane. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Is expressed in head and telencephalon. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brf1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellofaciodental syndrome	Alliance	Cerebellofaciodental syndrome	616202

Associated With brf1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011665	Brf1, TBP-binding domain
Domain	IPR013137	Zinc finger, TFIIB-type
Domain	IPR013150	Transcription factor TFIIB, cyclin-like domain
Domain	IPR013763	Cyclin-like domain
Family	IPR000812	Transcription factor TFIIB
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Length	Brf1, TBP-binding domain	Cyclin-like domain	Cyclin-like superfamily	Transcription factor TFIIB	Transcription factor TFIIB, cyclin-like domain	Zinc finger, TFIIB-type
UniProtKB:Q6P9Z3 InterPro	693

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brf1b-201 (1) Ensembl	Ensembl	3,011 nt	Select Tool ZFIN BLAST
mRNA	brf1b-203 (1) Ensembl	Ensembl	4,234 nt	Select Tool ZFIN BLAST
ncRNA	brf1b-002 (1) Ensembl	Ensembl	1,058 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations