Gene
ror1
- ID
- ZDB-GENE-030131-6104
- Name
- receptor tyrosine kinase-like orphan receptor 1
- Symbol
- ror1 Nomenclature History
- Previous Names
-
- fi34e02
- si:dkey-209n16.1
- wu:fi34e02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Predicted to be involved in positive regulation of intracellular signal transduction; positive regulation of kinase activity; and positive regulation of neuron projection development. Predicted to act upstream of or within protein phosphorylation and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gonad. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 108. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Bai et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 108 | Alliance | ?Deafness, autosomal recessive 108 | 617654 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR020067 | Frizzled domain |
| Family | IPR016247 | Tyrosine-protein kinase, receptor ROR |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
Domain Details Per Protein
| Protein | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, receptor ROR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QKB5
|
950 |
Interactions and Pathways
No data available
Plasmids
No data available