Gene
itgb5
- ID
- ZDB-GENE-030131-6022
- Name
- integrin, beta 5
- Symbol
- itgb5 Nomenclature History
- Previous Names
-
- wu:fi30h12
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in margin. Orthologous to human ITGB5 (integrin subunit beta 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ablooglu et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026818Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11845 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like domain, extracellular | Integrin beta, epidermal growth factor-like domain 1 | Integrin beta N-terminal | Integrin beta subunit | Integrin beta subunit, cytoplasmic domain | Integrin beta subunit, tail | Integrin beta subunit, VWA domain | Integrin beta tail domain superfamily | Integrin domain superfamily | PSI domain | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1MSX8
|
823 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16N5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-16P7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-89P3 | ZFIN Curated Data | |
| Contains | SNP | rs3728219 | ZFIN Curated Data | |
| Contains | SNP | rs3728220 | ZFIN Curated Data | |
| Contains | SNP | rs3728221 | ZFIN Curated Data | |
| Contains | SNP | rs3728222 | ZFIN Curated Data | |
| Contains | SNP | rs3728223 | ZFIN Curated Data | |
| Encodes | EST | fi30h12 | ||
| Encodes | cDNA | MGC:163102 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082836 (1) | 3363 nt | ||
| Genomic | GenBank:CR391905 (1) | 221511 nt | ||
| Polypeptide | UniProtKB:Q1MSX8 (1) | 823 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ITGB5 | 3 | Amino acid sequence comparison (1) |
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ablooglu, A.J., Tkachenko, E., Kang, J., and Shattil, S.J. (2010) Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development (Cambridge, England). 137(20):3449-3458
- Brown, K.E., Keller, P.J., Ramialison, M., Rembold, M., Stelzer, E.H., Loosli, F., and Wittbrodt, J. (2010) Nlcam modulates midline convergence during anterior neural plate morphogenesis. Developmental Biology. 339(1):14-25
- Nicoli, S., Standley, C., Walker, P., Hurlstone, A., Fogarty, K.E., and Lawson, N.D. (2010) MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 464(7292):1196-1200
- Garnett, A.T., Han, T.M., Gilchrist, M.J., Smith, J.C., Eisen, M.B., Wardle, F.C., and Amacher, S.L. (2009) Identification of direct T-box target genes in the developing zebrafish mesoderm. Development (Cambridge, England). 136(5):749-760
- Ablooglu, A.J., Kang, J., Handin, R.I., Traver, D., and Shattil, S.J. (2007) The zebrafish vitronectin receptor: Characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(8):2268-2276
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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