Gene

vwa1

ID

ZDB-GENE-030131-5921

Name

von Willebrand factor A domain containing 1

Symbol

vwa1 Nomenclature History

Previous Names

fi25e07
si:dkey-3p8.6 (1)
wu:fi25e07 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to be involved in growth plate cartilage chondrocyte morphogenesis. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Orthologous to human VWA1 (von Willebrand factor A domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wang et al., 2020

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vwa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive distal hereditary motor neuronopathy 7	Alliance	Neuronopathy, distal hereditary motor, autosomal recessive 7	619216

Associated With vwa1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
motor neuron disease	vu19Tg + MO2-vwa1	standard conditions	Pagnamenta et al., 2021
motor neuron disease	vu19Tg + CRISPR5-vwa1 + CRISPR6-vwa1	standard conditions	Pagnamenta et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR003961	Fibronectin type III
Family	IPR050525	Extracellular Matrix Assembly and Organization
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

Domain Details Per Protein

Protein	Length	Extracellular Matrix Assembly and Organization	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A
UniProtKB:E7FF10 InterPro	503

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vwa1-201 (1) Ensembl	Ensembl	1,980 nt	Select Tool
mRNA	vwa1-203 (1) Ensembl	Ensembl	734 nt	Select Tool
mRNA	vwa1-204 (1) Ensembl	Ensembl	5,483 nt	Select Tool ZFIN BLAST
ncRNA	vwa1-003 (1) Ensembl	Ensembl	630 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations