Gene

gclm

ID

ZDB-GENE-030131-5906

Name

glutamate-cysteine ligase, modifier subunit

Symbol

gclm Nomenclature History

Previous Names

GLCLR (1)
id:ibd3182
wu:fi24c07

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907712 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gclm Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Myocardial infarction, susceptibility to}	608446

Associated With gclm Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023210	NADP-dependent oxidoreductase domain
Family	IPR032963	Glutamate--cysteine ligase regulatory subunit
Homologous_superfamily	IPR036812	NADP-dependent oxidoreductase domain superfamily