Gene
spns2
- ID
- ZDB-GENE-030131-5843
- Name
- SPNS lysolipid transporter 2, sphingosine-1-phosphate
- Symbol
- spns2 Nomenclature History
- Previous Names
-
- fi20h04
- si:dkey-7b17.4
- toh
- wu:fi20h04
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable sphingolipid transporter activity. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; embryonic organ development; and sphingosine-1-phosphate receptor signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including blastodisc; cardiovascular system; intermediate cell mass of mesoderm; tail bud; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1110 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ko157 | Allele with one point mutation | Unknown | Unknown | ENU | |
| s8 | unknown | Unknown | Unknown | not specified | |
| s220 | unknown | Unknown | Unknown | not specified | |
| s420 | unknown | Unknown | Unknown | not specified | |
| sa1096 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10870 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20453 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sk12 | unknown | Unknown | Unknown | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 115 | Alliance | ?Deafness, autosomal recessive 115 | 618457 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily | Protein spinster-like |
|---|---|---|---|---|---|
|
UniProtKB:A2SWM2
|
504 | ||||
|
UniProtKB:A9JRX4
|
105 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-138A6 | Osborne et al., 2008 | |
| Contained in | BAC | DKEY-7B17 | Osborne et al., 2008 | |
| Contained in | BAC | DKEY-193H7 | ZFIN Curated Data | |
| Encodes | EST | fi20h04 | ||
| Encodes | cDNA | MGC:175116 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083847 (1) | 1515 nt | ||
| Genomic | GenBank:BX005059 (1) | 194603 nt | ||
| Polypeptide | UniProtKB:A2SWM2 (1) | 504 aa |
- Sone, R., Fujimaki, S., Kawahara, A. (2024) Efficient detection of single nucleotide variants in targeted genomic loci. Development, growth & differentiation. 66(2):172-177
- Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464
- Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
- Kawasaki, T., Maeno, A., Shiroishi, T., Sakai, N. (2017) Development and growth of organs in living whole embryo and larval grafts in zebrafish. Scientific Reports. 7:16508
- Langevin, C., Aleksejeva, E., Houel, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J.P., Boudinot, P. (2017) FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Frontiers in immunology. 8:617
- Nelson, A.C., Cutty, S.J., Gasiunas, S.N., Deplae, I., Stemple, D.L., Wardle, F.C. (2017) In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors. Cell Reports. 19:2782-2795
- Perland, E., Bagchi, S., Klaesson, A., Fredriksson, R. (2017) Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Open Biology. 7(9)
- Hisano, Y., Inoue, A., Okudaira, M., Taimatsu, K., Matsumoto, H., Kotani, H., Ohga, R., Aoki, J., Kawahara, A. (2015) Maternal and Zygotic Sphingosine Kinase 2 are Indispensable for Cardiac Development in Zebrafish. The Journal of biological chemistry. 290(24):14841-51
- Kotani, H., Taimatsu, K., Ohga, R., Ota, S., Kawahara, A. (2015) Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish. PLoS One. 10:e0128319
- Wang, X., Chong, M., Wang, X., Wang, H., Zhang, J., Xu, H., Zhang, J., Liu, D. (2015) Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro cellular & developmental biology. Animal. 51(3):211-7
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