Gene

spns2

ID
ZDB-GENE-030131-5843
Name
SPNS lysolipid transporter 2, sphingosine-1-phosphate
Symbol
spns2 Nomenclature History
Previous Names
  • fi20h04
  • si:dkey-7b17.4
  • toh
  • wu:fi20h04
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable sphingolipid transporter activity. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; embryonic organ development; and sphingosine-1-phosphate receptor signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including blastodisc; cardiovascular system; intermediate cell mass of mesoderm; tail bud; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
b1110Allele with one point mutationUnknownPremature StopENU
ko157Allele with one point mutationUnknownUnknownENU
s8unknownUnknownUnknownnot specified
s220unknownUnknownUnknownnot specified
s420unknownUnknownUnknownnot specified
sa1096Allele with one point mutationUnknownPremature StopENU
sa2192Allele with one point mutationUnknownPremature StopENU
sa10870Allele with one point mutationUnknownPremature StopENU
sa20453Allele with one point mutationUnknownPremature StopENU
sk12unknownUnknownUnknownnot specified
1 - 10 of 10
Show
Sequence Targeting Reagents
Human Disease
Associated With spns2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 115 Alliance ?Deafness, autosomal recessive 115 618457
1 - 1 of 1
Associated With spns2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020846 Major facilitator superfamily domain
Family IPR011701 Major facilitator superfamily
Family IPR044770 Protein spinster-like
Homologous_superfamily IPR036259 MFS transporter superfamily
1 - 4 of 4
Domain Details Per Protein
Protein Length Major facilitator superfamily Major facilitator superfamily domain MFS transporter superfamily Protein spinster-like
UniProtKB:A2SWM2 504
UniProtKB:A9JRX4 105
1 - 2 of 2
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA spns2-201 (1) Ensembl 2,138 nt
mRNA spns2-202 (1) Ensembl 1,192 nt
mRNA spns2-203 (1) Ensembl 6,001 nt
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-138A6Osborne et al., 2008
Contained inBACDKEY-7B17Osborne et al., 2008
Contained inBACDKEY-193H7ZFIN Curated Data
EncodesESTfi20h04
EncodescDNAMGC:175116ZFIN Curated Data
1 - 5 of 5
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSPNS217
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseSpns211
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
1 - 10 of 22
Show