Gene
grm4
- ID
- ZDB-GENE-030131-5781
- Name
- glutamate receptor, metabotropic 4
- Symbol
- grm4 Nomenclature History
- Previous Names
-
- fi18a01
- wu:fi18a01
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; cranial ganglion; motor neurons; and retinal neural layer. Orthologous to human GRM4 (glutamate metabotropic receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Haug et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017979 | GPCR, family 3, conserved site |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR011500 | GPCR, family 3, nine cysteines domain |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Family | IPR000162 | GPCR, family 3, metabotropic glutamate receptor |
1 - 5 of 10 Show all
Domain Details Per Protein
| Protein | Length | GPCR, family 3 | GPCR, family 3, conserved site | GPCR family 3, C-terminal | GPCR, family 3, metabotropic glutamate receptor | GPCR, family 3, metabotropic glutamate receptor 4 | GPCR, family 3, nine cysteines domain | GPCR, family 3, nine cysteines domain superfamily | Metabotropic Glutamate Receptor | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QAF2
|
705 | ||||||||||
|
UniProtKB:A0A8M9QFH1
|
906 | ||||||||||
|
UniProtKB:U3N863
|
912 | ||||||||||
|
UniProtKB:A0A8N7UTB5
|
916 |
1 - 4 of 4
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Ma, J., Gu, Y., Liu, J., Song, J., Zhou, T., Jiang, M., Wen, Y., Guo, X., Zhou, Z., Sha, J., He, J., Hu, Z., Luo, L., Liu, M. (2022) Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cellular and molecular life sciences : CMLS. 80:1919
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haug, M.F., Gesemann, M., Mueller, T., and Neuhauss, S.C. (2013) Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). The Journal of comparative neurology. 521(7):1533-1560
1 - 5 of 5
Show