Gene

prpf8

ID

ZDB-GENE-030131-577

Name

pre-mRNA processing factor 8

Symbol

prpf8 Nomenclature History

Previous Names

id:ibd1257
ik:tdsubc_2a9 (1)
im:7141966 (1)
tdsubc_2a9
wu:fb37c02
wu:fb73e06
xx:tdsubc_2a9
zgc:56504

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have pre-mRNA intronic binding activity and snRNA binding activity. Involved in spliceosomal tri-snRNP complex assembly. Predicted to localize to U5 snRNP and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Is expressed in brain. Orthologous to human PRPF8 (pre-mRNA processing factor 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141966 (1 image)
IMAGE:7137198 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Keightley et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prpf8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 13	Alliance	Retinitis pigmentosa 13	600059

Associated With prpf8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain
Domain	IPR012591	PRO8NT domain
Domain	IPR012592	PROCN domain
Domain	IPR012984	PROCT domain
Domain	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
Domain	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
Domain	IPR019582	RNA recognition motif, spliceosomal PrP8
Domain	IPR021983	PRP8 domain IV core
Domain	IPR037518	MPN domain
Family	IPR027652	Pre-mRNA-processing-splicing factor 8
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR042516	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
Homologous_superfamily	IPR043172	Prp8 RNase domain IV, palm region
Homologous_superfamily	IPR043173	Prp8 RNase domain IV, fingers region