Gene

kif14

ID

ZDB-GENE-030131-5759

Name

kinesin family member 14

Symbol

kif14 Nomenclature History

Previous Names

si:dkey-39e8.3
wu:fi16h07

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport and microtubule-based movement. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1117 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Reilly et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif14 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Microcephaly 20, primary, autosomal recessive	617914
		?Meckel syndrome 12	616258

Associated With kif14 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001752	Kinesin motor domain
Domain	IPR032405	Kinesin-associated
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily