Gene

pfkfb1

ID

ZDB-GENE-030131-5664

Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Symbol

pfkfb1 Nomenclature History

Previous Names

wu:fi11h10
zgc:55328

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to localize to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Is expressed in neural plate; neural tube; and somite. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55328 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfkfb1 Human Ortholog

No data available

Associated With pfkfb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain	IPR013079	6-phosphofructo-2-kinase
Family	IPR003094	Fructose-2,6-bisphosphatase
Family	IPR013078	Histidine phosphatase superfamily, clade-1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029033	Histidine phosphatase superfamily