Gene
rgs14a
- ID
- ZDB-GENE-030131-5579
- Name
- regulator of G protein signaling 14a
- Symbol
- rgs14a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within germ cell migration. Predicted to be located in dendrite. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in blastomere; epidermis; neural crest; and primordial germ cell. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66445 (1 image)
- IMAGE:7160274 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hartwig et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GoLoco motif | Raf-like Ras-binding | Regulator of G-protein signaling 10/12/14-like | Regulator of G-protein signaling 14, Ras-binding domain 1 | Regulator of G protein signaling 14, Ras-binding domain 2 | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B8C4
|
554 | ||||||||||
|
UniProtKB:Q7SXC7
|
532 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rgs14a-201
(1)
|
Ensembl | 2,495 nt | ||
| mRNA |
rgs14a-202
(1)
|
Ensembl | 647 nt | ||
| mRNA |
rgs14a-204
(1)
|
Ensembl | 859 nt | ||
| ncRNA |
rgs14a-004
(1)
|
Ensembl | 240 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-208H1 | ZFIN Curated Data | |
| Contained in | BAC | CH73-302A4 | ZFIN Curated Data | |
| Encodes | EST | fi04g12 | ||
| Encodes | EST | IMAGE:7160274 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66445 | ZFIN Curated Data |
1 - 5 of 5
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201304 (1) | 2466 nt | ||
| Genomic | GenBank:CU462913 (1) | 101884 nt | ||
| Polypeptide | UniProtKB:A0A8M3B8C4 (1) | 554 aa |
- Hansen, C.L., Chamberlain, T.J., Trevena, R.L., Kurek, J.E., Pelegri, F. (2021) Conserved germ plasm characteristics across the Danio and Devario lineages. Genesis (New York, N.Y. : 2000). 59(10):e23452
- Eno, C., Hansen, C.L., Pelegri, F. (2019) Aggregation, segregation and dispersal of homotypic germ plasm RNPs in the early zebrafish embryo. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(4):306-318
- Zhang, X., Li, X., Li, R., Zhang, Y., Li, Y., Li, S. (2019) Transcriptomic profile of early zebrafish PGCs by single cell sequencing. PLoS One. 14:e0220364
- Liao, H., Chen, Y., Yulong, L., Xue, S., Liu, M., Lin, Z., Liu, Y., Chan, H.C., Zhang, X., Sun, H. (2018) CFTR is required for the migration of Primordial Germ Cells during zebrafish early embryogenesis. Reproduction (Cambridge, England). 156(3):261-268
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hartwig, J., Tarbashevich, K., Seggewiß, J., Stehling, M., Bandemer, J., Grimaldi, C., Paksa, A., Groß-Thebing, T., Meyen, D., Raz, E. (2014) Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proceedings of the National Academy of Sciences of the United States of America. 111(31):11389-94
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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