Gene
eif2b5
- ID
- ZDB-GENE-030131-5364
- Name
- eukaryotic translation initiation factor 2B, subunit 5 epsilon
- Symbol
- eif2b5 Nomenclature History
- Previous Names
-
- fd14g07
- wu:fd14g07
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to act upstream of or within translational initiation. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in midbrain; myotome; optic vesicle; pharyngeal arch; and retina. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150951 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 5 | Alliance | Leukoencephalopathy with vanishing white matter 5, with or without ovarian failure | 620315 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter | eif2b5zc102/zc102 | standard conditions | Keefe et al., 2020 |
| leukoencephalopathy with vanishing white matter | eif2b5zc103/zc103 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003307 | W2 domain |
| Domain | IPR005835 | Nucleotidyl transferase domain |
| Domain | IPR035543 | Translation initiation factor eIF-2B subunit epsilon, N-terminal |
| Domain | IPR044123 | Translation initiation factor eIF-2B subunit epsilon, W2 domain |
| Family | IPR051956 | eIF2B Complex Subunit Epsilon |
| Homologous_superfamily | IPR011004 | Trimeric LpxA-like superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
| Repeat | IPR001451 | Hexapeptide repeat |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | eIF2B Complex Subunit Epsilon | Hexapeptide repeat | Nucleotide-diphospho-sugar transferases | Nucleotidyl transferase domain | Translation initiation factor eIF-2B subunit epsilon, N-terminal | Translation initiation factor eIF-2B subunit epsilon, W2 domain | Trimeric LpxA-like superfamily | W2 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WG65
|
703 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2b5-201
(1)
|
Ensembl | 1,832 nt |
Interactions and Pathways
No data available
Plasmids
No data available