Gene

nhp2

ID

ZDB-GENE-030131-533

Name

NHP2 ribonucleoprotein homolog (yeast)

Symbol

nhp2 Nomenclature History

Previous Names

nola2
wu:fb36b10
wu:fd61a03
zgc:73227

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have box H/ACA snoRNA binding activity. Predicted to be involved in nucleic acid metabolic process. Predicted to localize to box H/ACA snoRNP complex and telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Is expressed in several structures, including digestive system; immature eye; midbrain; retina; and segmental plate. Orthologous to human NHP2 (NHP2 ribonucleoprotein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73227 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nhp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive dyskeratosis congenita 2	Alliance	Dyskeratosis congenita, autosomal recessive 2	613987

Associated With nhp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45
Family	IPR002415	H/ACA ribonucleoprotein complex, subunit Nhp2-like
Family	IPR018492	Ribosomal protein eL8/Nhp2 family
Homologous_superfamily	IPR029064	Ribosomal protein eL30-like superfamily