Gene

polr1a

ID
ZDB-GENE-030131-5286
Name
RNA polymerase I subunit A
Symbol
polr1a Nomenclature History
Previous Names
  • fa26a03
  • sb:cb935
  • wu:fa26a03
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Acts upstream of or within embryonic viscerocranium morphogenesis; neural crest cell development; and rRNA transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin musculature; and segmental plate. Used to study acrofacial dysostosis Cincinnati type. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrofacial dysostosis Cincinnati type Alliance Acrofacial dysostosis, Cincinnati type 616462
Leukodystrophy, hypomyelinating, 27 620675
1 - 2 of 2
Associated With polr1a Via Experimental Models
Human Disease Fish Conditions Citations
acrofacial dysostosis Cincinnati type polr1ahi3639Tg/hi3639Tg control Watt et al., 2018
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000722 RNA polymerase, alpha subunit
Domain IPR006592 RNA polymerase, N-terminal
Domain IPR007066 RNA polymerase Rpb1, domain 3
Domain IPR007080 RNA polymerase Rpb1, domain 1
Domain IPR007081 RNA polymerase Rpb1, domain 5
1 - 5 of 12 Show all
Domain Details Per Protein
Protein Length DNA-directed RNA pol I, largest subunit, C-terminal domain DNA-directed RNA pol I, largest subunit, N-terminal domain DNA-directed RNA polymerase, subunit beta-prime RNA polymerase, alpha subunit RNA polymerase, N-terminal RNA polymerase Rpb1, clamp domain superfamily RNA polymerase Rpb1, domain 1 RNA polymerase Rpb1, domain 3 RNA polymerase Rpb1, domain 3 superfamily RNA polymerase Rpb1, domain 4 RNA polymerase Rpb1, domain 5 RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4I9V4
InterPro
1693
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA polr1a-201 (1)
Ensembl
Ensembl 5,286 nt
ZFIN BLAST
mRNA polr1a-202 (1)
Ensembl
Ensembl 7,583 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
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