Gene

slc25a4

ID

ZDB-GENE-030131-5275

Name

solute carrier family 25 member 4

Symbol

slc25a4 Nomenclature History

Previous Names

fa22e07
wu:fa22e07
zgc:77591

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to act upstream of or within mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in cephalic musculature; hypaxial myotome region; musculature system; myotome; and somite. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77591 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc25a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2	Alliance	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2	609283
mitochondrial DNA depletion syndrome 12a	Alliance	Mitochondrial DNA depletion syndrome 12A (cardiomyopathic type) AD	617184
mitochondrial DNA depletion syndrome 12b	Alliance	Mitochondrial DNA depletion syndrome 12B (cardiomyopathic type) AR	615418

Associated With slc25a4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002067	Mitochondrial carrier protein
Family	IPR002113	ADP/ATP carrier protein, eukaryotic type
Homologous_superfamily	IPR023395	Mitochondrial carrier domain superfamily
Repeat	IPR018108	Mitochondrial substrate/solute carrier