Gene
rpl5a
- ID
- ZDB-GENE-030131-5161
- Name
- ribosomal protein L5a
- Symbol
- rpl5a Nomenclature History
- Previous Names
-
- rpl5l
- mg:cb01f08
- zgc:77176
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable 5S rRNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within chordate embryonic development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in intestine; liver; and pancreas. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909214 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diamond-Blackfan anemia 6 | Alliance | Diamond-Blackfan anemia 6 | 612561 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Diamond-Blackfan anemia | AB + MO1-rpl5a | standard conditions | Wan et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Large ribosomal subunit protein uL18, C-terminal, eukaryotes | Large ribosomal subunit protein uL18 eukaryotic/archaeal |
|---|---|---|---|
|
UniProtKB:Q7ZUI0
|
297 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71A21 | ZFIN Curated Data | |
| Encodes | EST | cb01f08 | ||
| Encodes | EST | IMAGE:6909214 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56511 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77176 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199756 (1) | 1055 nt | ||
| Genomic | GenBank:CU855908 (1) | 45484 nt | ||
| Polypeptide | UniProtKB:Q7ZUI0 (1) | 297 aa |
- Flentke, G.R., Wilkie, T.E., Baulch, J., Huang, Y., Smith, S.M. (2024) Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 19:e0304557e0304557
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Berres, M.E., Garic, A., Flentke, G.R., Smith, S.M. (2017) Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis. PLoS One. 12:e0169351
- Wan, Y., Zhang, Q., Zhang, Z., Song, B., Wang, X., Zhang, Y., Jia, Q., Cheng, T., Zhu, X., Leung, A.Y., Yuan, W., Jia, H., Fang, X. (2016) Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC Medical Genomics. 9:13
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Wang, Y., and Zhang, S. (2011) Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Functional & integrative genomics. 11(1):111-118
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