Gene
eef2b
- ID
- ZDB-GENE-030131-5128
- Name
- eukaryotic translation elongation factor 2b
- Symbol
- eef2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Acts upstream of or within cellular response to xenobiotic stimulus and chordate embryonic development. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including epidermis; immature eye; nervous system; tail bud; and trunk. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19909 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 26 | Alliance | ?Spinocerebellar ataxia 26 | 609306 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000640 | Elongation factor EFG, domain V-like |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR005225 | Small GTP-binding domain |
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Domain Details Per Protein
| Protein | Length | EF-G domain III/V-like | Elongation factor EFG, domain V-like | Elongation Factor G, domain II | P-loop containing nucleoside triphosphate hydrolase | Ribosomal protein uS5 domain 2-type superfamily | Small GTP-binding domain | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Translational (tr)-type GTP-binding domain | Translation elongation factor EFG/EF2, domain IV | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P3J5
|
858 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250D7 | ZFIN Curated Data | |
| Encodes | EST | cegs191 | Rauch et al., 2003 | |
| Encodes | EST | fe49h02 | ||
| Encodes | EST | IMAGE:6895891 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:6902416 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55904 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77674 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200458 (1) | 2826 nt | ||
| Genomic | GenBank:CU651576 (2) | 90414 nt | ||
| Polypeptide | UniProtKB:Q6P3J5 (2) | 858 aa |
- Leesch, F., Lorenzo-Orts, L., Pribitzer, C., Grishkovskaya, I., Roehsner, J., Chugunova, A., Matzinger, M., Roitinger, E., Belačić, K., Kandolf, S., Lin, T.Y., Mechtler, K., Meinhart, A., Haselbach, D., Pauli, A. (2023) A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature. 613(7945):712-720
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hurem, S., Martín, L.M., Brede, D.A., Skjerve, E., Nourizadeh-Lillabadi, R., Lind, O.C., Christensen, T., Berg, V., Teien, H.C., Salbu, B., Oughton, D.H., Aleström, P., Lyche, J.L. (2017) Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. PLoS One. 12:e0179259
- Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20
- Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311
- De Wit, M., Keil, D., van der Ven, K., Vandamme, S., Witters, E., and De Coen, W. (2010) An integrated transcriptomic and proteomic approach characterising estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). General and comparative endocrinology. 167(2):190-201
- Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
- Zhang, S.H., Yao, J.H., Song, H.D., Wang, L., and Xue, J.L. (2008) Cloning and expression of translation elongation factor 2 (EF-2) in zebrafish. DNA sequence : the journal of DNA sequencing and mapping. 19(1):1-7
- Zhang, S.H., Yao, J.H., Song, H.D., Wang, L., and Xue, J.L. (2006) Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish. The International journal of developmental biology. 50(4):399-403
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
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