Gene
slc41a1
- ID
- ZDB-GENE-030131-4700
- Name
- solute carrier family 41 member 1
- Symbol
- slc41a1 Nomenclature History
- Previous Names
-
- fd54c09
- wu:fd54c09
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable monoatomic cation transmembrane transporter activity. Acts upstream of or within chordate embryonic development; magnesium ion homeostasis; and pronephros development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; corpuscles of Stannius; gill; liver; and pleuroperitoneal region. Orthologous to human SLC41A1 (solute carrier family 41 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017898Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa44746 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Nephronophthisis-like nephropathy 2 | 619468 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | SLC41A divalent cation transporter | SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily | SLC41A/MgtE, integral membrane domain |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q0L4
|
544 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc41a1-201
(1)
|
Ensembl | 3,144 nt | ||
| mRNA |
slc41a1-202
(1)
|
Ensembl | 1,635 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-59D2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-112F3 | ZFIN Curated Data | |
| Encodes | EST | fd54c09 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423792 (1) | 4446 nt | ||
| Genomic | GenBank:AL929596 (1) | 191874 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0L4 (1) | 544 aa |
- Arjona, F.J., Latta, F., Mohammed, S.G., Thomassen, M., van Wijk, E., Bindels, R.J.M., Hoenderop, J.G.J., de Baaij, J.H.F. (2018) SLC41A1 is essential for magnesium homeostasis in vivo. Pflugers Archiv : European journal of physiology. 471(6):845-860
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hurd, T.W., Otto, E.A., Mishima, E., Gee, H.Y., Inoue, H., Inazu, M., Yamada, H., Halbritter, J., Seki, G., Konishi, M., Zhou, W., Yamane, T., Murakami, S., Caridi, G., Ghiggeri, G., Abe, T., and Hildebrandt, F. (2013) Mutation of the Mg2+ Transporter SLC41A1 Results in a Nephronophthisis-Like Phenotype. Journal of the American Society of Nephrology : JASN. 24(6):967-977
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938
1 - 6 of 6
Show