Gene

tcn2

ID

ZDB-GENE-030131-4648

Name

transcobalamin II

Symbol

tcn2 Nomenclature History

Previous Names

tcn2l
si:ch211-102c2.6
wu:fd46e10 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits cobalamin binding activity. Predicted to be involved in cobalamin transport. Human ortholog(s) of this gene implicated in Parkinson's disease; congenital intrinsic factor deficiency; megaloblastic anemia; pernicious anemia; and transcobalamin II deficiency. Is expressed in yolk syncytial layer. Orthologous to several human genes including TCN2 (transcobalamin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7162514 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Benoit et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcn2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
transcobalamin II deficiency	Alliance	Transcobalamin II deficiency	275350

Associated With tcn2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
vitamin B12 deficiency	tcn2^{zf3057/zf3057} (AB/TU)	standard conditions	Benoit et al., 2021
vitamin B12 deficiency	tcn2^{zf3057/zf3057} (AB/TU)	standard conditions	Benoit et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR027954	Transcobalamin-like, C-terminal domain
Family	IPR002157	Cobalamin (vitamin B12)-binding protein
Family	IPR051588	Eukaryotic Cobalamin Transport