Gene
vegfab
- ID
- ZDB-GENE-030131-4605
- Name
- vascular endothelial growth factor Ab
- Symbol
- vegfab Nomenclature History
- Previous Names
-
- fd42e02 (1)
- si:dkey-14d8.3
- wu:fd42e02
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor 1 binding activity. Involved in phosphorylation and sprouting angiogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); reproductive organ cancer (multiple); and retinal disease (multiple). Is expressed in nervous system; pronephros; and vasculature. Orthologous to human VEGFA (vascular endothelial growth factor A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Microvascular complications of diabetes 1} | 603933 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023581 | Platelet-derived growth factor, conserved site |
| Domain | IPR000072 | PDGF/VEGF domain |
| Domain | IPR027928 | Vascular endothelial growth factor, heparin-binding domain |
| Family | IPR050507 | Platelet-derived/Vascular endothelial growth factor |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
| Homologous_superfamily | IPR036841 | Vascular endothelial growth factor, heparin-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived/Vascular endothelial growth factor | Vascular endothelial growth factor, heparin-binding domain | Vascular endothelial growth factor, heparin-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BBS4
|
250 | ||||||
|
UniProtKB:Q0QYI0
|
194 | ||||||
|
UniProtKB:A0A8M3B1G0
|
227 | ||||||
|
UniProtKB:A0A8M1P9F8
|
252 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vegfab-201
(1)
|
Ensembl | 600 nt | ||
| mRNA |
vegfab-202
(1)
|
Ensembl | 2,198 nt | ||
| mRNA |
vegfab-203
(1)
|
Ensembl | 2,227 nt |
Interactions and Pathways
No data available
Plasmids
No data available