Gene
sec24c
- ID
- ZDB-GENE-030131-4487
- Name
- SEC24 homolog C, COPII coat complex component
- Symbol
- sec24c Nomenclature History
- Previous Names
-
- im:7145364
- wu:fd10d12
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular protein transport. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in gut and head. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145364 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sarmah et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17715 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31889 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35346 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Gelsolin-like domain superfamily | Sec23/Sec24 beta-sandwich | SEC23/SEC24 family, SEC24 subfamily | Sec23/Sec24, helical domain | Sec23/Sec24 helical domain superfamily | Sec23/Sec24, trunk domain | Sec24-like, trunk domain | von Willebrand factor A-like domain superfamily | Zinc finger, Sec23/Sec24-type | Zinc finger, Sec23/Sec24-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IMX2
|
1248 | ||||||||||||
|
UniProtKB:A0A8M2B375
|
1277 | ||||||||||||
|
UniProtKB:A0A8M6Z9C2
|
1291 | ||||||||||||
|
UniProtKB:A0A0R4IAZ9
|
1300 | ||||||||||||
|
UniProtKB:A0A8M2B330
|
1271 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sec24c-202
(1)
|
Ensembl | 5,678 nt | ||
| mRNA |
sec24c-203
(1)
|
Ensembl | 4,239 nt | ||
| mRNA |
sec24c-204
(1)
|
Ensembl | 484 nt | ||
| ncRNA |
sec24c-004
(1)
|
Ensembl | 528 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-108L19 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-322E5 | ||
| Encodes | EST | fd10d12 | ||
| Encodes | EST | IMAGE:7145364 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001245968 (1) | 5678 nt | ||
| Genomic | GenBank:CU694198 (2) | 42823 nt | ||
| Polypeptide | UniProtKB:A0A0R4IAZ9 (1) | 1300 aa |
- Le Corre, S., Eyre, D., Drummond, I.A. (2014) Modulation of the Secretory Pathway Rescues Zebrafish Polycystic Kidney Disease Pathology. Journal of the American Society of Nephrology : JASN. 25(8):1749-59
- Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85
- Melville, D.B., Montero-Balaguer, M., Levic, D.S., Bradley, K., Smith, J.R., Hatzopoulos, A.K., and Knapik, E.W. (2011) The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Disease models & mechanisms. 4(6):763-76
- Sarmah, S., Barrallo-Gimeno, A., Melville, D.B., Topczewski, J., Solnica-Krezel, L., and Knapik, E.W. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 5(4):e10367
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