Gene

arid1b

ID

ZDB-GENE-030131-4459

Name

AT-rich interactive domain 1B

Symbol

arid1b Nomenclature History

Previous Names

fd07d11
si:dkey-60a16.3
wu:fd07d11

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to contribute to nucleosome binding activity. Predicted to be involved in ATP-dependent chromatin remodeling; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to localize to SWI/SNF complex; nBAF complex; and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome; Coffin-Siris syndrome 1; intellectual disability; and neuroblastoma. Orthologous to human ARID1B (AT-rich interaction domain 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Doldur-Balli et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arid1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Coffin-Siris syndrome 1	Alliance	Coffin-Siris syndrome 1	135900

Associated With arid1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001606	ARID DNA-binding domain
Domain	IPR033388	SWI/SNF-like complex subunit BAF250, C-terminal
Domain	IPR038040	AT-rich interactive domain-containing protein 1B, ARID domain
Family	IPR021906	SWI/SNF-like complex subunit BAF250/Osa
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036431	ARID DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	ARID DNA-binding domain	ARID DNA-binding domain superfamily	Armadillo-like helical	Armadillo-type fold	AT-rich interactive domain-containing protein 1B, ARID domain	SWI/SNF-like complex subunit BAF250, C-terminal	SWI/SNF-like complex subunit BAF250/Osa
UniProtKB:A0A0R4ISW4 InterPro	2122
UniProtKB:A0A2R8RJE4 InterPro	2081
UniProtKB:A0A8M3B3X6 InterPro	2123
UniProtKB:A0A8M2B764 InterPro	2169
UniProtKB:A0A8M2B773 InterPro	2170
UniProtKB:A0A8M2B7I1 InterPro	2169

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arid1b-201 (1) Ensembl	Ensembl	8,791 nt	Select Tool
mRNA	arid1b-202 (1) Ensembl	Ensembl	8,905 nt	Select Tool ZFIN BLAST
mRNA	arid1b-203 (1) Ensembl	Ensembl	8,782 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations