Gene

pfas

ID
ZDB-GENE-030131-4420
Name
phosphoribosylformylglycinamidine synthase
Symbol
pfas Nomenclature History
Previous Names
  • fd05a06
  • si:dkey-183n20.16
  • wu:fd05a06
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have phosphoribosylformylglycinamidine synthase activity. Predicted to be involved in purine nucleobase biosynthetic process. Predicted to localize to cytoplasm. Is expressed in brain; digestive system; eye; heart; and muscle. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Li et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pfas Human Ortholog
No data available
Associated With pfas Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010918 PurM-like, C-terminal domain
Domain IPR040707 Phosphoribosylformylglycinamidine synthase, N-terminal
Domain IPR041609 Phosphoribosylformylglycinamidine synthase, linker domain
Family IPR010073 Phosphoribosylformylglycinamidine synthase PurL
Homologous_superfamily IPR029062 Class I glutamine amidotransferase-like
Homologous_superfamily IPR036604 Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily
Homologous_superfamily IPR036676 PurM-like, C-terminal domain superfamily
Homologous_superfamily IPR036921 PurM-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Class I glutamine amidotransferase-like Phosphoribosylformylglycinamidine synthase, linker domain Phosphoribosylformylglycinamidine synthase, N-terminal Phosphoribosylformylglycinamidine synthase PurL Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily PurM-like, C-terminal domain PurM-like, C-terminal domain superfamily PurM-like, N-terminal domain superfamily
UniProtKB:Q5TZ72 1314
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pfas-201 (1) Ensembl 5,174 nt
ncRNA pfas-002 (1) Ensembl 455 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations